| Article Details : |
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| | | Article Name : | | | Frequency and Outcome of Acute Kidney Injury in SARS | | Author Name : | | | Abdulrahman Ishag, Rehab Sirelkhatim Mustafa Musa, Elrasheid Ali Awouda, Elfadil Mohammed Osman, Farah Riyad Gafar Mohamed, Mursi Mohammed Alhassan, Faris Riyad | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Background: Coronavirus disease 2019 (COVID-19) causes multiple organ injuries; acute kidney injury (AKI) is a critical complication due to its high incidence and mortality rate. Many studies have agreed that AKI is an important complication of COVID-19 infection.
Objective: To determine the frequency and outcome of AKI among SARS-CoV-2 patients in Khartoum State, as well as identify the associated risk factors that predispose individuals to AKI.
Study design: This was a retrospective hospital-based study conducted at Khartoum Teaching Hospital, Royal Care, and Fedail Hospital during the period from September to December 2021 and included all admitted patients with COVID-19. The data were entered in 2021 and analyzed using SPSS version 25.
Results: This study covered 170 participants, with a frequency of AKI among the participants of (n=113, 66.5%). The analysis found significant associations between a higher frequency of AKI among patients with sepsis and hemodynamic instability (with a p value < 0.05 in all cases). While the frequency of AKI was higher among patients with comorbidities such as hypertension, diabetes, and CVD, the association was not statistically significant. Management was conservative in (n=35, 31%) of the cases, while RRT was required in (n=78, 69%). The overall mortality was (n=83, 48.8%), which was significantly higher among AKI cases (with p = 0.001).
Conclusion: Our study has demonstrated a significant prevalence of AKI among hospitalized COVID patients. Over half of the study population required mechanical ventilation, specifically invasive ventilation. Furthermore, a substantial proportion of patients necessitated RRT, with CRRT being more commonly administered than conventional RRT methods. Notably, hemodynamic instability and sepsis emerged as prominent risk factors for AKI development. Additionally, our study established a significant correlation between the use of vasopressors and the occurrence of AKI. Finally, this study has also shown that AKI increases the mortality rate among COVID patients.
| | Keywords : | | | Acute kidney injury, COVID-19, Sepsis, Haemodialysis, Khartoum, Sudan. |
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